Offer - Toxicological studies

The list below contains our standard studies; however, some other studies may be introduced and conducted on request.

Acute toxicity studies “6-pack”
ACUTE TOXICITY STUDIES “6-PACK” METHOD
Acute oral toxicity – fixed dose procedure OECD No. 420/EU B.1.BIS
Acute intraperitoneal/ subcutaneous/ intravascular toxicity OECD No. 420/EU B.1.BIS
Acute oral toxicity – acute toxic class method OECD No. 423/EU B.1.TRIS
Acute dermal toxicity OECD No. 402/EU B.3
Acute inhalation toxicity OECD No. 403
In vitro skin corrosion: transcutaneous electrical resistance test (TER) OECD No. 430
Isolated chicken eye test method for identifying i) chemicals including serious eye damage and ii) chemicals not requiring classifications for eye irritation or serious eye damage (ICE) OECD No. 438
Acute skin irritation/ corrosion OECD No. 404/EU B.4
Acute eye irritation/ corrosion OECD No. 405/EU B.5
Skin sensitization OECD No. 406/EU B.6
Skin sensitization OECD No. 442B
In chemico skin sensitisation, Direct peptide reactivity assay (DPRA)
OECD No. 442C
Subacute toxicity studies
SUBACUTE TOXICITY STUDIES METHOD
Repeated dose 28-day oral toxicity study in rodents OECD No. 407/EU B.7
Repeated dose 28-day intraperitoneal/ subcutaneous toxicity study in rodents OECD No. 407/EU B.7
Repeated dose dermal toxicity: 21/28 day study OECD No. 410/EU B.9
Subchronic toxicity studies
SUBCHRONIC TOXICITY STUDIES METHOD
Repeated dose 90-day oral toxicity study in rodents OECD No. 408/EU B.26
Subchronic dermal toxicity: 90-day study OECD No. 411/EU B.28
Chronic toxicity and carcinogenicity studies
CHRONIC TOXICITY AND CARCINOGENICITY STUDIES METHOD
Chronic toxicity studies OECD No. 452/EU B.30
Carcinogenicity studies OECD No. 451/EU B.32
Combined chronic toxicity/ carcinogenicity studies OECD No. 453/EU B.33
Reproduction toxicity studies
REPRODUCTION TOXICITY STUDIES METHOD
Prenatal developmental toxicity study OECD No. 414/EU B.31
Reproduction / developmental toxicity screening test OECD No. 421
One-generation reproduction toxicity study OECD No. 415/EU B.34
Extended one-generation reproductive toxicity study
OECD No. 443
Two-generation reproduction toxicity study OECD No. 416/EU B.35
Neurotoxicity study
NEUROTOXICITY STUDY METHOD
Neurotoxicity study in rodents OECD No. 424/EU B.43
Local tolerance study
LOCAL TOLERANCE STUDY METHOD
Local tolerance test OECD No. 404, CPMP/SWP/2145/00, ISO 10993-10
Genotoxicity studies
GENOTOXICITY STUDIES METHOD
Bacterial Reverse Mutation Test (AMES Test)
OECD Nr 471
In vivo mammalian alkaline comet assay
OECD No. 489


For any questions do not hestitate to contact us ipo@ipo-pszczyna.pl or planowanie@ipo-pszczyna.pl


Department of Toxicology

Toxicological tests performed at the IPO can be characterized as follows:
  • they allow a toxicological evaluation of chemical substances contained in pharmaceutical products, veterinary medicinal products, plant protection products, food and feed additives, industrial chemical substances, etc.,
  • they make it possible to elaborate models which allow one to observe chemical substances in the body and to explain the mechanisms of various toxic effects caused by them,
  • they serve as a basis for a routine evaluation of new chemical compounds,
  • their results are used to register and license industrial chemical substances in compliance with specific regulations.